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Mycosis fungoides and chronic lymphocytic leukaemia – composite T-cell and B-cell lymphomas presenting in the skin

✍ Scribed by P.R. Hull; A. Saxena

Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
632 KB
Volume
143
Category
Article
ISSN
0007-0963

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✦ Synopsis

Composite lymphomas involving cutaneous B-cell and T-cell lymphomas are very uncommon. We report here the unique circumstance of a patient with mycosis fungoides (primary cutaneous T-cell lymphoma) who later developed chronic lymphocytic leukaemia (B-cell lymphoproliferation, B-CLL), which presented in the skin (leukaemia cutis) as a composite lymphoma affecting an earlobe. The presence of both lymphoproliferative disorders was confirmed with immunophenotyping and the finding of both immunoglobulin gene rearrangements and T-cell receptor gene rearrangements in the ear and the same T-cell receptor gene rearrangement in a plaque lesion of mycosis fungoides on the arm.

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