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Mycophenolic acid glucuronidation and its inhibition by non-steroidal anti-inflammatory drugs in human liver and kidney

✍ Scribed by M. Vietri; A. Pietrabissa; F. Mosca; G.M. Pacifici

Book ID
105922437
Publisher
Springer
Year
2000
Tongue
English
Weight
113 KB
Volume
56
Category
Article
ISSN
0031-6970

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The inhibitory potencies of non-steroidal anti-inflammatory drugs (NSAIDs) on UDP-glucuronosyltransferase (UGT) 1A9 activity were investigated in recombinant human UGT1A9 using 4-methylumbelliferone (4-MU) as a substrate for glucuronidation. 4-MU glucuronidation (4-MUG) showed Michaelis-Menten kinet