MycN and IFNγ cooperate in apoptosis of human neuroblastoma cells
✍ Scribed by Lutz, Werner; Fulda, Simone; Jeremias, Irmela; Debatin, Klaus-Michael; Schwab, Manfred
- Book ID
- 110060461
- Publisher
- Nature Publishing Group
- Year
- 1998
- Tongue
- English
- Weight
- 485 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0950-9232
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## Abstract __MYCN__ and insulin‐like growth factor (IGF) system are important for the pathogenesis and development of neuroblastoma. We previously reported evidence of a direct linkage between MycN and the IGF system in KP‐N‐RT human neuroblastoma cells, where IGF‐I induced both MycN expression at
We characterized differences in the structural organization of the MYCN amplicons of a number of neuroblastomas by analyzing 8 contigs spanning 330 kb cloned from the MYCN amplicon of a neuroblastoma cell line. Some regions were amplified in almost all specimens, the conserved regions (CRs), and oth