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Myc and Max proteins possess distinct transcriptional activities

✍ Scribed by Kretzner, Leo; Blackwood, Elizabeth M.; Eisenman, Robert N.

Book ID
109781890
Publisher
Nature Publishing Group
Year
1992
Tongue
English
Weight
629 KB
Volume
359
Category
Article
ISSN
0028-0836

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## Abstract Deregulated __CMYC__ gene causes cell transformation and is often correlated with tumor progression and a worse clinical outcome of cancer patients. The transcription factor Myc functions by heterodimerizing with its partner, Max. As a strategy to inhibit Myc activity, we have synthesiz