Myasthenic sera recognize the human acetylcholine receptor bound to thymopoietin

T cells from normal and myasthenic indiv

T cells from normal and myasthenic individuals recognize the human acetylcholine receptor: Heterogeneity of antigenic sites on the α-subunit

✍ Dr A. Melms; G. Malcherek; U. Gern; H. Wiethölter; C. A. Müller; R. Schoepfer; J 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 846 KB

The a-subunit of the nicotinic acetylcholine receptor is the major target of the autoimmune response in myasthenia gravis. We investigated the proliferative response of T cells from patients with myasthenia gravis and healthy volunteers to recombinant polypeptides of the human acetylcholine receptor