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Myasthenia gravis, paraneoplastic pemphigus and thymoma, a rare triade

✍ Scribed by D. T. Winkler; P. Strnad; M. L. Meier; S. Roten; P. Went; P. Lyrer; A. J. Steck


Publisher
Springer
Year
2007
Tongue
English
Weight
253 KB
Volume
254
Category
Article
ISSN
0340-5354

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Malignant thymoma (MT) is a rare tumor that is often associated with myasthenia gravis (MG). This tumor is considered resistant to chemotherapy. We had the opportunity to treat five patients with MT with cyclophosphamide 800 mg/m2, Adriamycin 50 mg/m2, and vincristine 1.4 mg/m2 (CAV) in cycles of 21

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Of 134 patients with thymoma, 79 (59%) also had myasthenia gravis (MG). The thymoma with MG differed from that in the absence of MG in the following aspects: The ratio of lymphocytes to epithelial cells in the tumor was larger, the polygonal cell type was more prominent (i.e., in 83% of the MG patie