My favourite molecule: Discovery of the nucleolar targeting signal

✍ Scribed by Masakazu Hatanaka

• Book ID: 102758488
• Publisher: John Wiley and Sons
• Year: 1990
• Tongue: English
• Weight: 733 KB
• Volume: 12
• Category: Article
• ISSN: 0265-9247
• DOI: 10.1002/bies.950120310

✦ Synopsis

The discovery of the signal peptides that direct proteins to localize at the nucleolus is described here. The nucleolar targeting signal termed the NOS consists of clustered basic amino acids organized such that a portion also functions as the nuclear transporting signal. Although a NOS has been identified within the regulatory genes of human retroviruses, HTLV-I and HIV-I, signals of similar function in cellular proteinssuch as heat shock proteinsmay be induced through the configurational change of protein structure by heat or stress.