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Mutual exclusiveness between PIK3CA and KRAS mutations in endometrial carcinoma

✍ Scribed by S. KANG; S.S. SEO; H.J. CHANG; C.W. YOO; S.Y. PARK; S.M. DONG

Book ID: 109086377
Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 73 KB
Volume: 18
Category: Article
ISSN: 1048-891X
DOI: 10.1111/j.1525-1438.2007.01172.x

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## Abstract While the phosphatidylinositol 3‐kinase (PI3K)/AKT signaling pathway is known to be activated in multiple sporadic cancers, the role of this pathway in familial tumors is mostly unknown. We searched for alterations in the catalytic domain of PI3K (__PIK3CA__), PTEN and __KRAS__, all of