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Mutations of ZFPM2/FOG2 gene in sporadic cases of tetralogy of Fallot

✍ Scribed by Antonio Pizzuti; Anna Sarkozy; Anthea L. Newton; Emanuela Conti; Elisabetta Flex; Maria Cristina Digilio; Francesca Amati; Debora Gianni; Caterina Tandoi; Bruno Marino; Merlin Crossley; Bruno Dallapiccola

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
119 KB
Volume
22
Category
Article
ISSN
1059-7794

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✦ Synopsis

FIGURE 3. The E30S and S657G mutations do not signiΒ’cantly impair binding to the partner protein GATA4. A: GST pull-down assay showing retention of wild-type ZFPM2/FOG2, the E30S and S657G mutants by GATA4 N-Β’nger. Input lanes show that equivalent amounts of wild-type and mutant ZFPM2/FOG2 proteins were used. B: Coomassie-stained gel indicating that approximately equal amounts of GST-GATA4 N-Β’nger and GSTwere used in the pull-down assay.

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