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Mutations of the p53 gene, including an intronic point mutation, in colorectal tumors

✍ Scribed by Chikashi Ishioka; Toshiaki Sato; Makio Gamoh; Takao Suzuki; Hiroyuki Shibata; Ryunosuke Kanamaru; Akira Wakui; Tadasu Yamazaki

Book ID
115763975
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
752 KB
Volume
177
Category
Article
ISSN
0006-291X

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## Background: Mutations of the p53 tumor suppressor gene play an integral role in sporadic colorectal carcinogenesis but prior studies have failed to show their prognostic significance consistently. ## Methods: Fifty-six consecutive sporadic colorectal tumors were analyzed for their p53 status.