Mutations in the p53 gene are associated with a wide variety of human malignancies. Point mutation in one allele and loss of the remaining one generally lead to inactivation of p53 protein. A high frequency of allelic losses corresponding to the I7p 13.3 region that contained the p53 gene sequence
Mutations of the p53 gene in carcinomas of the urinary system
โ Scribed by Yasushi Suzuki; Gen Tamura
- Book ID
- 115175010
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 576 KB
- Volume
- 43
- Category
- Article
- ISSN
- 1320-5463
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## Abstract Abnormalities of the __p53__ gene are frequently observed in human tumors, including urinary bladder carcinoma, suggesting that __p53__ plays an important role in human carcinogenesis. However, its role in rat bladder carcinogenesis is unclear. We investigated __p53__ gene mutations and