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Mutations of the Mouse Twist and sy (Fibrillin 2) Genes Induced by Chemical Mutagenesis of ES Cells

✍ Scribed by Victoria L. Browning; Shazia S. Chaudhry; Antonio Planchart; Michael J. Dixon; John C. Schimenti

Book ID
115615426
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
225 KB
Volume
73
Category
Article
ISSN
0888-7543

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## Abstract 2‐Amino‐3,4‐dimethylimidazo[4,5‐__f__]quinoline (MelQ), a food mutagen, induces forestomach tumors in CDF~1~ mice. We established a polymerase chain reaction (PCR)–single‐strand conformation polymorphism (SSCP) analysis system to detect mutations in the mouse __p53__ gene exons 2–10, wh