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Mutations of optineurin in amyotrophic lateral sclerosis

โœ Scribed by Maruyama, Hirofumi; Morino, Hiroyuki; Ito, Hidefumi; Izumi, Yuishin; Kato, Hidemasa; Watanabe, Yasuhito; Kinoshita, Yoshimi; Kamada, Masaki; Nodera, Hiroyuki; Suzuki, Hidenori

Book ID
109898854
Publisher
Nature Publishing Group
Year
2010
Tongue
English
Weight
672 KB
Volume
465
Category
Article
ISSN
0028-0836

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## Abstract Three clustered, homologous paraoxonase genes (__PON1__, __PON2,__ and __PON3__) have roles in preventing lipid oxidation and detoxifying organophosphates. Recent reports describe a genetic association between the __PON__ genes and sporadic amyotrophic lateral sclerosis (ALS). We now re