Mutations Induced by the Carcinogenic Pyrrolizidine Alkaloid Riddelliine in the Liver cII Gene of Transgenic Big Blue Rats
โ Scribed by Mei, Nan; Heflich, Robert H.; Chou, Ming W.; Chen, Tao
- Book ID
- 126253617
- Publisher
- American Chemical Society
- Year
- 2004
- Tongue
- English
- Weight
- 50 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0893-228X
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Big Blue ยฎ mice harbor a recoverable transgene in a lambda/LIZ shuttle vector. In the standard assay, in vivo mutations are measured in the bacterial lacI gene using a labor-intensive color plaque assay. Applying a simpler assay : Proc Natl Acad Sci USA 93:9073-9078], we measured mutations in the la
The potent rat liver carcinogen 6-p-dimethylaminophenylazobenzthiazole (6BT) and its reported noncarcinogenic analogue 5-p-dimethylaminophenylazobenzthiazole (5BT; evaluated for carcinogenicity under the similar limited bioassay conditions used for 6BT) have been studied in order to seek an explanat