Mutations in the RAD27 and SGS1 genes differentially affect the chronological and replicative lifespan of yeast cells growing on glucose and glycerol

Running on empty: Does mitochondrial DNA

Running on empty: Does mitochondrial DNA mutation limit replicative lifespan in yeast? : Mutations that increase the division rate of cells lacking mitochondrial DNA also extend replicative lifespan in Saccharomyces cerevisiae

✍ Cory D. Dunn 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 139 KB 👁 2 views

## Abstract Mitochondrial DNA (mtDNA) mutations escalate with increasing age in higher organisms. However, it has so far been difficult to experimentally determine whether mtDNA mutation merely correlates with age or directly limits lifespan. A recent study shows that budding yeast can also lose fu