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Mutations in the P. falciparum Digestive Vacuole Transmembrane Protein PfCRT and Evidence for Their Role in Chloroquine Resistance

✍ Scribed by Fidock, David A. (author);Nomura, Takashi (author);Talley, Angela K. (author);Cooper, Roland A. (author);Dzekunov, Sergey M. (author);Ferdig, Michael T. (author);Ursos, Lyann M.B. (author);Bir Singh Sidhu, Amar (author);Naudé, Bronwen (author);Deitsch, Kirk W. (author);Su, Xin Zhuan (author);Wootton, John C. (author);Roepe, Paul D. (author);Wellems, Thomas E. (author)

Book ID
117737460
Publisher
Cell Press
Year
2000
Tongue
English
Weight
438 KB
Volume
6
Category
Article
ISSN
1097-2765

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✍ Maha E. Osman; Frank P. Mockenhaupt; Ulrich Bienzle; Mustafa I. Elbashir; Hayder 📂 Article 📅 2007 🏛 Elsevier Science 🌐 English ⚖ 349 KB

Mutations in the Plasmodium falciparum pfcrt gene on chromosome 7 and possibly mutations in pfmdr1 on chromosome 5 have a role in conferring resistance against chloroquine (CQ), as do mutations of pfdhfr on chromosome 4 and pfdhps on chromosome 8 in terms of resistance against sulfadoxine/pyrimetham