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Mutations in the mitochondrial ATPase6 gene are frequent in human osteosarcoma

✍ Scribed by Guo, Xue-Guang; Liu, Chang-Ting; Dai, Huanzi; Guo, Qiao-Nan


Book ID
122763222
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
484 KB
Volume
94
Category
Article
ISSN
0014-4800

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## Abstract The smallest rotary motor of living cells, F0F1‐ATP synthase, couples proton flowβ€”generated by the OXPHOS systemβ€”from the intermembrane space back to the matrix with the conversion of ADP to ATP. While all mutations affecting the multisubunit complexes of the OXPHOS system probably impa