Mutations in the dystrophin gene are associated with sporadic dilated cardiomyopathy
โ Scribed by Jinong Feng; Jin Yan; Carolyn H Buzin; Jeffrey A Towbin; Steve S Sommer
- Book ID
- 117735437
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 219 KB
- Volume
- 77
- Category
- Article
- ISSN
- 1096-7192
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Thymopoietin or TMPO (indicated by its alternative gene symbol, LAP2, in this work) has been proposed as a candidate disease gene for dilated cardiomyopathy (DCM), since a LAP2 product associates with nucleoplasmic lamins A/C, which are encoded by the DCM gene LMNA. We developed a study to screen fo
Dilated cardiomyopathy (DCM) results in part from genetic disorders. Recently, missense mutations of the cardiac actin gene have been reported to cause DCM. We studied 136 Japanese DCM cases to elucidate how frequently the gene mutations are involved in its pathogenesis. Genomic DNA samples were obt