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Mutations in the DNA polymerase and thymidine kinase genes of herpes simplex virus clinical isolates resistant to antiherpetic drugs

✍ Scribed by A. N. Korovina; A. A. Gus’kova; M. Yu. Skoblov; V. L. Andronova; G. A. Galegov; S. N. Kochetkov; M. K. Kukhanova; Yu. S. Skoblov


Book ID
110174809
Publisher
SP MAIK Nauka/Interperiodica
Year
2010
Tongue
English
Weight
189 KB
Volume
44
Category
Article
ISSN
0026-8933

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Drug-resistance of herpes simplex virus (HSV) is caused most frequently by mutation of the viral thymidine kinase (TK) gene. To elucidate the significance of detecting nucleotide changes of the TK gene for screening drug-resistant viruses, the frequency and variation of the genetic polymorphisms in