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Mutations in the Carboxyl Terminus of the Agouti Protein Decrease Agouti Inhibition of Ligand Binding to the Melanocortin Receptors

✍ Scribed by Kiefer, Laura L.; Ittoop, Olivia R. R.; Bunce, Keith; Truesdale, Anne T.; Willard, Derril H.; Nichols, James S.; Blanchard, Steven G.; Mountjoy, Kathleen; Chen, Wen-Ji; Wilkison, William O.


Book ID
126913100
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
242 KB
Volume
36
Category
Article
ISSN
0006-2960

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Current trends in the structure—activity
✍ Andrzej M. Wilczynski; Christine G. Joseph; Carrie Haskell-Luevano 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 264 KB

## Abstract Agouti‐related protein (AGRP) is an endogenous antagonist of the melanocortin‐3 and ‐4 (MC3R and MC4) G‐protein coupled receptors. The 87–132 amino acid C‐terminal domain of hAGRP possesses five disulfide bridges and a well‐defined three‐dimensional structure that displays full biologic