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Mutations in the basic core promoter region of hepatitis B virus. Relationship with precore variants and HBV genotypes in a Spanish population of HBV carriers

✍ Scribed by Rosendo Jardi; Francisco Rodriguez; Maria Buti; Xose Costa; Auristela Valdes; Helena Allende; Melanie Schaper; Roman Galimany; Rafael Esteban; Jaime Guardia

Book ID: 116650207
Publisher: Elsevier Science
Year: 2004
Tongue: English
Weight: 290 KB
Volume: 40
Category: Article
ISSN: 0168-8278
DOI: 10.1016/j.jhep.2003.11.015

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Spontaneous mutations of hepatitis B virus (HBV) could influence the severity of liver disease. Since the basal core promoter (BCP) and the precore (Pc) regions are important for viral replication, these regions were examined for naturally occurring mutations and were correlated with the genotype, e