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Mutations in the ABCC8 gene encoding the SUR1 subunit of the KATP channel cause transient neonatal diabetes, permanent neonatal diabetes or permanent diabetes diagnosed outside the neonatal period

✍ Scribed by A. M. Patch; S. E. Flanagan; C. Boustred; A. T. Hattersley; S. Ellard


Book ID
109044547
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
299 KB
Volume
9
Category
Article
ISSN
1462-8902

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Glucokinase is a key regulatory enzyme in the pancreatic beta-cell. It plays a crucial role in the regulation of insulin secretion and has been termed the glucose sensor in pancreatic beta-cells. Given its central role in the regulation of insulin release it is understandable that mutations in the g