Mutations in ARHGEF6, encoding a guanine nucleotide exchange factor for Rho GTPases, in patients with X-linked mental retardation

Characterization ofARHGEF6, a guanine nu

Characterization ofARHGEF6, a guanine nucleotide exchange factor for Rho GTPases and a candidate gene for X-linked mental retardation: Mutation screening in B�rjeson-Forssman-Lehmann syndrome and MRX27

✍ Lower, Karen M. ;Gecz, Jozef 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 83 KB 👁 2 views

Bo È rjeson-Forssman-Lehmann syndrome (BFLS) is a syndromic X-linked mental retardation that has been mapped by linkage to Xq26±q27. A nonsyndromic mental retardation family, MRX27, has also been localized to a region of the X chromosome overlapping Xq26±q27. The gene for ARH-GEF6 (also known as aPI