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Mutations determining generalized resistance to aminoglycoside antibiotics in Escherichia coli

✍ Scribed by Thorbjarnard�ttir, Sigr��ur H. ;Magn�sd�ttir, Ragnhei�ur �. ;Eggertsson, Gu�mundur ;Kagan, Sarah A. ;Andr�sson, �lafur S.

Publisher: Springer
Year: 1978
Tongue: English
Weight: 830 KB
Volume: 161
Category: Article
ISSN: 0026-8925
DOI: 10.1007/bf00266619

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✦ Synopsis

Mutations conferring resistance to low levels of kanamycin in Escherichia coli have been mapped at 3 locations: the unc locus (min. 83), a locus we have designated kanA (MIN. 72), close to strA (rpsL), and a locus at min. 86.5 previously discovered by Plate (1976) that we have designated ecfB. The unc and ecfB mutations are associated with defects in energy metabolism, while mutations at kanA may be in the gene coding for ribosomal protein S12 (rpsL). The three types of mutations cause cross resistance to a number of different aminoglycoside antibiotics and the effects of the mutations are cumulative in combination.

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