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Mutations Changing the Kinetics of Class II MHC Peptide Exchange

✍ Scribed by Nancy Wilson; Daved Fremont; Philippa Marrack; John Kappler

Book ID
117723054
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
562 KB
Volume
14
Category
Article
ISSN
1074-7613

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he allele-specific peptidebinding motifs of major histocompatibility complex (MHC) proteins, originally discovered by pool sequencing of MHC class I-bound peptides 1 , provide a biochemical basis for the phenomenon of MHC restriction of T-cell responses. However, the analysis of class II peptide mot