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Mutations at positions 186 and 194 in the HA gene of the 2009 H1N1 pandemic influenza virus improve replication in cell culture and eggs

✍ Scribed by Pirada Suphaphiphat; Michael Franti; Armin Hekele; Anders Lilja; Terika Spencer; Ethan Settembre; Gene Palmer; Stefania Crotta; Annunziata B Tuccino; Bjoern Keiner; Heidi Trusheim; Kara Balabanis; Melissa Sackal; Mithra Rothfeder; Christian W Mandl; Philip R Dormitzer; Peter W Mason


Book ID
119908334
Publisher
BioMed Central
Year
2010
Tongue
English
Weight
705 KB
Volume
7
Category
Article
ISSN
1743-422X

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## Abstract Pandemic influenza A/H1N1 2009 (A/H1N1pdm) virus caused significant outbreaks worldwide last year (2009). A number of oseltamivir‐resistant A/H1N1pdm viruses possessing an H275Y substitution in the neuraminidase (NA) protein were reported sporadically in several countries, including Jap