## Abstract Gap junctions are mediated by intercellular channels that connect adjacent cells and are composed of Connexin (Cx) proteins. A member of the Cx family, Cx26 is considered a potential tumor suppressor in several cancers. The expression of __Cx26__ gene and its methylation status in rat l
Mutations and Reduced Expression of the Transforming Growth Factor-β Receptor II Gene in Rat Lung Adenocarcinomas Induced byN-Nitrosobis-(2-hydroxypropyl)amine
✍ Scribed by Tsujiuchi, Toshifumi ;Sasaki, Yasutaka ;Tsutsumi, Masahiro ;Konishi, Yoichi
- Book ID
- 108581849
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 2000
- Tongue
- English
- Weight
- 78 KB
- Volume
- 91
- Category
- Article
- ISSN
- 0910-5050
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To clarify the involvement of the Rassf1a gene in lung carcinogenesis, we investigated the methylation status in the 5 0 upstream region of the RAS-association domain family 1, isoform A (Rassf1a) gene in rat lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine (BHP). Six-week-old male
## Abstract Alterations of the mannose 6‐phosphate/insulin‐like growth factor II receptor (__M6p/lgf2r__) gene were investigated in lung adenocarcinomas induced by N‐nitrosobis(2‐hydroxypropyl)amine (BHP) in rats. Male Wistar rats, 6 wk old, were given 2000 ppm BHP in their drinking water for 12 wk