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Mutational Switching of a Yeast tRNA Synthetase into a Mammalian-like Synthetase Cytokine †

✍ Scribed by Liu, Jianming; Yang, Xiang-Lei; Ewalt, Karla L.; Schimmel, Paul

Book ID
121461717
Publisher
American Chemical Society
Year
2002
Tongue
English
Weight
252 KB
Volume
41
Category
Article
ISSN
0006-2960

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✍ Xiang-Lei Yang; Jianming Liu; Robert J. Skene; Duncan E. McRee; Paul Schimmel 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 German ⚖ 290 KB

## Abstract Aminoacyl‐tRNA synthetases catalyze the first step of protein synthesis by aminoacylation of tRNAs. Remarkably, biological fragments of two human enzymes – tyrosyl‐tRNA synthetase (TyrRS) and tryptophanyl‐tRNA synthetase – are active cytokines produced by proteolysis or alternative spli