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Mutational specificity of mice defective in the MTH1 and/or the MSH2 genes

✍ Scribed by Akinori Egashira; Kazumi Yamauchi; Kaoru Yoshiyama; Hisaya Kawate; Motoya Katsuki; Mutsuo Sekiguchi; Keizo Sugimachi; Hisaji Maki; Teruhisa Tsuzuki

Book ID: 117798872
Publisher: Elsevier Science
Year: 2002
Tongue: English
Weight: 470 KB
Volume: 1
Category: Article
ISSN: 1568-7864
DOI: 10.1016/s1568-7864(02)00113-1

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## Abstract Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant disorder that predisposes to predominantly colorectal and endometrial cancers due to germline mutations in DNA mismatch repair genes, mainly __MLH1__, __MSH2__ and in families with excess endometrial cancer also