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Mutational and Structural Analysis of Stem-loop IIIc of the Hepatitis C Virus and GB Virus B Internal Ribosome Entry Sites

✍ Scribed by Rene Rijnbrand; Varatharasa Thiviyanathan; Kumaralal Kaluarachchi; Stanley M. Lemon; David G. Gorenstein

Book ID: 116661634
Publisher: Elsevier Science
Year: 2004
Tongue: English
Weight: 708 KB
Volume: 343
Category: Article
ISSN: 0022-2836
DOI: 10.1016/j.jmb.2004.08.095

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## Abstract The extreme 5′‐proximal sequence of the hepatitis C virus (HCV) genome including the 5′ non‐coding region (5′NCR) of 341 nucleotide long and the first 30 nucleotides of the core region is highly conserved among different HCV genotypes. It contains a segment termed Internal Ribosome Entr