Mutational analysis of thyroid transcription factor-1 gene (TTF-1) in lung carcinomas
β Scribed by Xiao Yan Bai; Hong Shen
- Book ID
- 107427022
- Publisher
- Society for In Vitro Biology
- Year
- 2007
- Tongue
- English
- Weight
- 473 KB
- Volume
- 44
- Category
- Article
- ISSN
- 1475-2689
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Neuroendocrine tumors of the lung consist of a spectrum of neoplasms, including typical carcinoids, atypical carcinoids, large-cell neuroendocrine carcinomas (LCNEC), and small-cell lung carcinomas (SCLC). We previously reported frequent inactivation of the gene responsible for multiple endocrine ne
## Abstract Summary: The __Thyroid transcription factorβ1 (TTFβ1)__ gene belongs to the __Nkxβ2.1__ subfamily and encodes a transcription factor containing an NKβ2βtype homeodomain. In our study, we isolated and characterized cDNA clones for the __TTFβ1/Nkxβ2.1__ orthologue __(LjTTFβ1)__ from the a