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Mutational Analysis of the Role of Tryptophan Residues in an Antimicrobial Peptide †

✍ Scribed by Fimland, Gunnar; Eijsink, Vincent G. H.; Nissen-Meyer, Jon


Book ID
127040074
Publisher
American Chemical Society
Year
2002
Tongue
English
Weight
122 KB
Volume
41
Category
Article
ISSN
0006-2960

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## Abstract Bovine lactoferricin is a 25‐residue antibacterial peptide isolated after gastric cleavage of the iron transporting protein lactoferrin. A 15‐residue fragment, FKCRRWQWRMKKLGA of this peptide sustains most of the antibacterial activity. In this truncated sequence, the two Trp residues a