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Mutational analysis of the estrogen-receptor gene in endometrial carcinoma

โœ Scribed by Matthew F. Kohler; Alexander Berkholz; John I. Risinger; Alaa Elbendary; Jeff Boyd; Andrew Berchuck


Book ID
116039015
Publisher
Lippincott Williams and Wilkins
Year
1995
Tongue
English
Weight
633 KB
Volume
86
Category
Article
ISSN
0029-7844

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Mutations in the estrogen receptor gene
โœ Mels Sluyser ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 674 KB

Somatically generated mutations in the estrogen receptor (ER) have been found at the mRNA/cDNA level in human breast cancer biopsies and in established breast cancer cell lines. Aberrantly spliced ER mRNA causes the appearance of truncated or internally deleted ER protein forms. Studies on the funct