Non-small cell lung cancers have a high incidence of somatic mutations of the beta-tubulin (class I) gene, suggesting involvement in the acquisition of resistance to taxanes, which exert their effects through binding to beta-tubulin. Since taxanes are often used in the treatment of breast cancer, we
Mutational analysis of the class i beta-tubulin gene in renal cell carcinoma (RCC)
β Scribed by Roisean E Ferguson; Claire F Taylor; Anthea J Stanley; Roger M Phillips; Adrian D Joyce; Patricia A Harnden; Poulam M Patel; Peter J Selby; Rosamonde E Banks
- Book ID
- 118645179
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 89 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1569-9056
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract To delineate more precisely the somatic von HippelβLindau disease (VHL) gene alteration as well as to elucidate its etiologic role in renal tumorigenesis, we examined a total of 240 sporadic renal cell carcinomas (RCCs) for somatic __VHL__ gene alterations by DNAβSSCP followed by sequen
## Communicated by Albert de la Chapelle To investigate the nature of somatic von Hippel-Lindau (VHL) mutations, we analyzed 173 primary sporadic human renal cell carcinomas for mutations of the VHL tumor suppressor gene, using polymerase chain reaction (PCR) and single-strand conformational polym
## Loss of heterozygosity (LOH ) at chromosome band 10q23 occurs frequently in a wide variety of human tumors. A recently identified candidate tumor suppressor gene, PTEN located on 10q23, is mutated in multiple advanced cancers. To explore whether PTEN is associated with human squamous cell carci