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Mutational analysis of telomere genes in BRCA1/2-negative breast cancer families with very short telomeres

✍ Scribed by Kira Yanowsky, Alicia Barroso, Ana Osorio, Miguel Urioste, Javier Benitez, Beatriz Martinez-Delgado

Book ID
118796658
Publisher
Springer US
Year
2012
Tongue
English
Weight
243 KB
Volume
134
Category
Article
ISSN
0167-6806

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About 5-10% of breast cancer cases are hereditary and attributable to mutations in several susceptibility genes from which to date only 2 have been identified: BRCA1 (17q21) and BRCA2 (13q12). However, the BRCA genes only explain about 30% of familial breast/ovarian cancer, suggesting the existence