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Mutational analysis of p73 and p53 in human cancer cell lines

✍ Scribed by Yoshikawa, Hirohide; Nagashima, Makoto; Khan, Mohammed A; McMenamin, Mary G; Hagiwara, Koichi; Harris, Curtis C

Book ID
110062107
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
676 KB
Volume
18
Category
Article
ISSN
0950-9232

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In primary breast cancer, mutations of the p53 tumor suppressor gene lead to loss of growth-suppressive properties and poor outcome. Recently, a p53-related gene, termed p73, has been cloned and its gene product possesses a function similar to p53. p73 has been mapped at chromosome 1p36.3, a region

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## Abstract __p53__‐related genes, __p73__ and __p63__, encode 2 classes of proteins, TA‐p73/p63 and Ξ”N‐p73/p63. TA‐p73/p63 demonstrate p53‐like properties including gene transactivation and cell death promotion, whereas Ξ”N‐p73/p63 lack these p53‐like functions. Although p53‐deficient cancer cells