Mutational analysis of human endothelin receptors ETA and ETB : Identification of regions involved in the selectivity for endothelin 3 or cyclo-(d-Trp-d-Asp-Pro-d-Val-Leu)

Location of alkali metal binding sites i

Location of alkali metal binding sites in endothelin A selective receptor antagonists, cyclo(D-Trp-D-Asp-Pro-D-Val-Leu) and cyclo(D-Trp-D-Asp-Pro-D-Ile-Leu), from multistep collisionally activated decompositions

✍ Ngoka, Lambert C. M.; Gross, Michael L. 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 216 KB 👁 2 views

We previously showed by using mass spectrometry that endothelin A selective receptor antagonists BQ123 and JKC301 form novel coordination compounds with sodium ions. This property may underlie the ability of an ET A antagonist to induce net tubular sodium reabsorption in the proximal tubule cells an