Mutational analysis of a protein-folding pathway
β Scribed by Goldenberg, David P.; Frieden, Richard W.; Haack, Julie A.; Morrison, Thomas B.
- Book ID
- 109758171
- Publisher
- Nature Publishing Group
- Year
- 1989
- Tongue
- English
- Weight
- 660 KB
- Volume
- 338
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/338127a0
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The equilibrium folding pathway of staphylococcal nuclease (SNase) has been approximated using a statistical thermodynamic formalism that utilizes the highresolution structure of the native state as a template to generate a large ensemble of partially folded states. Close to 400,000 different states
## Abstract This review discusses the inherent challenge of linking βreductionistβ approaches to decipher the information encoded in protein sequences with burgeoning efforts to explore protein folding in native environmentsββpostreductionistβ approaches. Because the invitation to write this articl