Three common mutations in the CARD15 (NOD2) gene are known to be associated with susceptibility to Crohn disease (CD), and genetic data suggest a gene dosage model with an increased risk of 2-4-fold in heterozygotes and 20-40-fold in homozygotes. However, the discovery of numerous rare variants of C
Mutation, selection, and evolution
โ Scribed by Errol Zeiger
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 15 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0893-6692
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๐ SIMILAR VOLUMES
Professor de Vries having found in nature races that seem to have arisen suddenly, fully formed, and having repeatedly observed mutating individuals that breed true, declares, in his " Mutationstheorie," for the universality of mutation as the method of phylogenetic differentiation. He says (1901, p
Fisher's Fundamental Theorem of Natural Selection is extended to the selection mutation model with mutation rates epsilon ij = epsilon i, i.e. depending only on the target gene, by constructing a simple Lyapunov function. For other mutation rates stable limit cycles are possible.
Artificial selection results in biolgical changes, creating artificial evolution. When using selection indexes, the artificial evolution depends on the relative economic (or other) weight of traits in the breeding objective, and on the phenotypic and genetic variances and covariances among these tra