## Communicated by Johannes Zschocke A method for mutation detection in the alpha-1 antitrypsin gene (protease inhibitor 1; PI) has been developed using denaturing gradient gel electrophoresis of PCR amplified gene fragments. Using this experimental approach, all common phenotypes and mutations co
Mutation screening using fluorescence multiplex denaturing gradient gel electrophoresis (FMD): detecting mutations in the BRCA1 gene
β Scribed by Zhang, Shiyu; Kuperstein, Graciela; Narod, Steven A
- Book ID
- 109946011
- Publisher
- Nature Publishing Group
- Year
- 2006
- Tongue
- English
- Weight
- 339 KB
- Volume
- 1
- Category
- Article
- ISSN
- 1750-2799
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## Communicated by John A. Phillips III Denaturing gradient gel electrophoresis (DGGE) is commonly used to search for point mutations in DNA fragments amplified in vitro by the polymerase chain reaction (PCR). For the complete detection of mutations in large genes with many exons, the DGGE-PCR app