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Mutation screening of the CARD15 gene in sarcoidosis

✍ Scribed by M. Akahoshi; M. Ishihara; K. Namba; N. Kitaichi; Y. Ando; S. Takenaka; T. Ishida; S. Ohno; N. Mizuki; H. Nakashima; T. Shirakawa


Book ID
110892773
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
92 KB
Volume
71
Category
Article
ISSN
0001-2815

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Three common mutations in the CARD15 (NOD2) gene are known to be associated with susceptibility to Crohn disease (CD), and genetic data suggest a gene dosage model with an increased risk of 2-4-fold in heterozygotes and 20-40-fold in homozygotes. However, the discovery of numerous rare variants of C