𝔖 Bobbio Scriptorium
✦   LIBER   ✦

MUTATION OF THEVHL GENE IS ASSOCIATED EXCLUSIVELY WITH THE DEVELOPMENT OF NON-PAPILLARY RENAL CELL CARCINOMAS

✍ Scribed by KENCK, CHRISTIANE; WILHELM, MÓNICA; BUGERT, PETER; STAEHLER, GERD; KOVACS, GYULA

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
478 KB
Volume
179
Category
Article
ISSN
0022-3417

No coin nor oath required. For personal study only.

✦ Synopsis

To define the possible role of the VHL gene in the development of sporadic renal cell carcinomas, 91 different parenchymal tumours of the kidney have been investigated for mutation of the VHL gene by single strand conformation polymorphism (SSCP) andlor heteroduplex (HD) techniques. Chromosome 3p deletion was detected in 98 per cent of non-papillary renal cell carcinomas and in 25 per cent of chromophobe renal cell carcinomas. In 22 of the 43 non-papillary renal cell carcinomas, abnormally migrating DNA bands were detected by SSCP andlor HD analysis. No mobility shift was seen in any of the 23 chromophobe renal cell carcinomas. In addition, 15 papillary renal cell tumours and ten renal oncocytomas, which are characterized by genetic changes other than loss of chromosomc 3p sequences, were analysed for mutation of the VHL gene. None of these tumours showed abnormal migration patterns. The results indicate that mutation of the VHL gene is associated exclusively with the development o f non-papillary renal cell carcinoma.

📜 SIMILAR VOLUMES

Loss of heterozygosity at chromosomes 8p
Loss of heterozygosity at chromosomes 8p, 9p, and 14q is associated with stage and grade of non-papillary renal cell carcinomas
✍ Schullerus, Dietlinde; Herbers, Jutta; Chudek, Jerzy; Kanamaru, Hiroshi; Kovacs, 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 92 KB 👁 1 views

In this study, 105 non-papillary renal cell carcinomas (RCCs) have been examined for allelic loss at the chromosome 8p12-21.1, 9p21, and 14q24.2-qter regions, each by two highly polymorphic microsatellites. Loss of heterozygosity (LOH) was detected at both chromosome 8p and 9p in 33 per cent of the

Activation of the MN/CA9 gene is associa
Activation of the MN/CA9 gene is associated with hypomethylation in human renal cell carcinoma cell lines
✍ Masaki Cho; Karin Grabmaier; Yoshiteru Kitahori; Yoshio Hiasa; Yoshinori Nakagaw 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 134 KB 👁 2 views

The MN/CA9 (G250) gene expressed in the normal alimentary tract in a tissue-specific manner is often activated in renal cell carcinomas. To cast light on the activation mechanism, we examined the methylation status of this gene in seven human renal cell carcinoma cell lines and three normal kidney t

Allelic loss at the D9S171 locus on chro
Allelic loss at the D9S171 locus on chromosome 9p13 is associated with progression of papillary renal cell carcinoma
✍ Schraml, P.; M�ller, D.; Bednar, R.; Gasser, Th.; Sauter, G.; Mihatsch, M. J.; M 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 110 KB 👁 1 views

Papillary renal cell carcinomas (RCCs) have characteristic clinical and morphological features that separate them from the more common clear cell RCCs. The details of the molecular changes in papillary RCC progression are not well understood. In this study, four highly polymorphic microsatellite mar

The tcf17 gene at chromosome 5q is not i
The tcf17 gene at chromosome 5q is not involved in the development of conventional renal cell carcinoma
✍ Peter Bugert; Tamas Pesti; Gyula Kovacs 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 French ⚖ 118 KB 👁 1 views

The human Kid-1 homolog Tcf17 has been cloned and assigned to chromosome 5q35.3. Since the chromosome 5q22qter region is duplicated in approximately 50% of conventional renal-cell carcinomas, it was suggested that Tcf17 is involved in the development of renal tumors. We have analyzed Tcf17 mRNA in n

Mutations of the VHL gene in sporadic re
Mutations of the VHL gene in sporadic renal cell carcinoma: Definition of a risk factor for VHL patients to develop an RCC
✍ C. Gallou; D. Joly; A. Méjean; F. Staroz; N. Martin; G. Tarlet; M.T. Orfanelli; 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 332 KB 👁 2 views

## Communicated by Albert de la Chapelle To investigate the nature of somatic von Hippel-Lindau (VHL) mutations, we analyzed 173 primary sporadic human renal cell carcinomas for mutations of the VHL tumor suppressor gene, using polymerase chain reaction (PCR) and single-strand conformational polym