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Mutation of the POU-domain gene Brn4/Pou3f4 affects middle-ear sound conduction in the mouse

✍ Scribed by Daniel S. Samadi; James C. Saunders; E. Bryan Crenshaw III


Book ID
116524643
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
477 KB
Volume
199
Category
Article
ISSN
0378-5955

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## Abstract Brn4/Pou3f4 is a POU‐domain transcription factor expressed in the otic mesenchyme that is required for the normal development of the inner ear. In this report, we describe the isolation of an otic mesenchyme enhancer in the __Brn4__ gene. Subsequently, this enhancer was used to drive th