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Mutation of the mouse klotho gene leads to a syndrome resembling ageing

โœ Scribed by Kuro-o, Makoto; Nabeshima, Yo-ichi; Matsumura, Yutaka; Aizawa, Hiroki; Kawaguchi, Hiroshi; Suga, Tatsuo; Utsugi, Toshihiro; Ohyama, Yoshio; Kurabayashi, Masahiko; Kaname, Tadashi; Kume, Eisuke; Iwasaki, Hitoshi; Iida, Akihiro; Shiraki-Iida, Takako; Nishikawa, Satoshi; Nagai, Ryozo


Book ID
109784048
Publisher
Nature Publishing Group
Year
1997
Tongue
English
Weight
594 KB
Volume
390
Category
Article
ISSN
0028-0836

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We evaluated an autopsy case with severe neonatal respiratory distress, hypoplasia of thymus, thyroid gland and cerebellum, and agenesis of the corpus callosum displaying striking phenotypic similarity to the CrebA knockout mouse. On the assumption that comparable genetic alterations must be present