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Mutation of the class I β-tubulin gene does not predict response to paclitaxel for breast cancer

✍ Scribed by Kazuma Maeno; Ken-ichi Ito; Yoshihisa Hama; Kiyoshi Shingu; Morihiko Kimura; Muneaki Sano; Hiroshi Nakagomi; Shin-ichi Tsuchiya; Minoru Fujimori


Book ID
117467845
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
198 KB
Volume
198
Category
Article
ISSN
0304-3835

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Mutational analysis of the class I β-tub
✍ Seiichi Hasegawa; Yasuo Miyoshi; Chiyomi Egawa; Makoto Ishitobi; Yasuhiro Tamaki 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 French ⚖ 244 KB

Non-small cell lung cancers have a high incidence of somatic mutations of the beta-tubulin (class I) gene, suggesting involvement in the acquisition of resistance to taxanes, which exert their effects through binding to beta-tubulin. Since taxanes are often used in the treatment of breast cancer, we