Mutational analysis of the class I β-tub
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Seiichi Hasegawa; Yasuo Miyoshi; Chiyomi Egawa; Makoto Ishitobi; Yasuhiro Tamaki
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Article
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2002
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John Wiley and Sons
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French
⚖ 244 KB
Non-small cell lung cancers have a high incidence of somatic mutations of the beta-tubulin (class I) gene, suggesting involvement in the acquisition of resistance to taxanes, which exert their effects through binding to beta-tubulin. Since taxanes are often used in the treatment of breast cancer, we