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Mutation of the Androgen-Receptor Gene in Metastatic Androgen-Independent Prostate Cancer

✍ Scribed by Taplin, Mary-Ellen; Bubley, Glenn J.; Shuster, Todd D.; Frantz, Martha E.; Spooner, Amy E.; Ogata, George K.; Keer, Harold N.; Balk, Steven P.

Book ID
124152543
Publisher
Massachusetts Medical Society
Year
1995
Tongue
English
Weight
94 KB
Volume
332
Category
Article
ISSN
0096-6762

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Prostate cancer is considered to be one of the most hormone-dependent human malignancies. As a key mediator of hormonal response, the androgen receptor (AR) is believed to have an important role in the progression of prostate cancer. Mutations in the coding region of the AR gene have been found in b