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Mutation is modulated: implications for evolution

โœ Scribed by Lynn Helena Caporale

Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
116 KB
Volume
22
Category
Article
ISSN
0265-9247

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โœฆ Synopsis

Evolution occurs through genome variation followed by selection. Because DNA sequence context affects the activity of enzymes that copy, move and repair DNA, there are intrinsic variations in the probability of genetic variation along a genome. These intrinsic variations can be affected by selective pressure. Codon changes that do not alter the encoded amino acids may still have effects on the local rate of sequence change. Large gene families could encode a successful genetic framework by which to evolve new, functional members. The speed of adaptation to environmental challenges may be improved when the distinct mechanisms of genetic change come under regulatory control. Natural selection operates on mechanisms that generate and modulate diversity as it does on all biological functions. BioEssays 22:388ยฑ395, 2000.

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Adaptive mutation: implications for evol
Adaptive mutation: implications for evolution
โœ Patricia L. Foster ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 161 KB

Adaptive mutation is defined as a process that, during nonlethal selections, produces mutations that relieve the selective pressure whether or not other, nonselected mutations are also produced. Examples of adaptive mutation or related phenomena have been reported in bacteria and yeast but not yet o