Clinical signs and symptoms in a large h
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Anthony P. Nicholas; Elizabeth O'Hearn; Susan E. Holmes; Dung-Tsa Chen; Russell
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Article
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2004
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John Wiley and Sons
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English
⚖ 108 KB
## Abstract The most common form of autosomal dominant hereditary spastic paraparesis (HSP), SPG4, is caused by mutations in the spastin gene on chromosome 2p. This disease is characterized by intra‐ and interfamilial phenotypic variation. To determine the predictive values of clinical signs and sy