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Mutation in human bile salt exporter pump causes progressive familial intrahepatic cholestasis

✍ Scribed by Dan Gordon


Book ID
118521857
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
904 KB
Volume
116
Category
Article
ISSN
0016-5085

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The bile salt export pump (Bsep) represents the major bile salt transport system at the canalicular membrane of hepatocytes. When examined in model cell lines, genetic mutations in the BSEP gene impair its targeting and transport function, contributing to the pathogenesis of progressive familial int