To determine whether adefovir is active against lamivudine-resistant hepatitis B virus (HBV), the inhibition constants of adefovir diphosphate and lamivudine triphosphate for wild-type and mutant human HBV DNA polymerases, which contain amino acid substitutions associated with lamivudine resistance,
Mutation in HBV RNA-dependent DNA polymerase confers resistance to lamivudine in vivo
โ Scribed by G A Tipples; M M Ma; K P Fischer; V G Bain; N M Kneteman; D L Tyrrell
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 221 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0270-9139
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